Study register · detail
The Clinical Significance of Endocannabinoids in Endometriosis Pain Management
Unclear
65 citations
SampleNarrative Review
Blindingn.a.
DesignNarrative Review
Key finding
Narrative review without primary data collection; describes theoretical mechanisms of the endocannabinoid system in endometriosis pain management, without reporting specific intervention outcomes.
Summary
Narrative review on the role of the endocannabinoid system in endometriosis pain; discusses CB1/CB2 receptor expression in endometrial lesions, preclinical data on PEA/anandamide effects on inflammation and pain modulation; no RCTs or systematic clinical evidence, primarily a mechanistic-exploratory approach with an outlook on therapeutic potential.
SummaryNarrative review on the role of the endocannabinoid system (ECS) in pain management in endometriosis. Discusses pathophysiological mechanisms and potential therapeutic approaches through ECS modulation — no empirical data from clinical studies presented.
Quality profile
Sample size
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Blinding
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Citations / year
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Abstract
Introduction: Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of pain is often insufficient and is associated with high rate of recurrence. Better pain management is therefore of urgent need. Methods: Among the various candidates, the endocannabinoid system (ECS) has recently emerged as a relevant pharmacological target for the management of endometriosis-related pain. A computerized literature search was performed to identify relevant studies combining the keywords "endometriosis," "endocannabinoid," "cannabinoid receptor," "THC," and "pain mechanisms." Conclusions: This review describes the multiple and complex pain mechanisms associated with endometriosis. Current data and theories concerning the link between the ECS and pain management for endometriosis patients are presented. Finally, we will discuss which aspects of endometriosis-associated pain can be targeted by modulation of the ECS.
The impediment to action advances action.