Study register / Autonomic / Other / Fatigue

Fatigue

1 curated study · 1 key study · mechoulam.de

For fatigue, the evidence remains limited so far and stems mostly from the palliative care setting. Further studies are needed for reliable conclusions.

Rating scheme

The letter rates the quality of a study, independently of its type. Every study type can receive any grade: a review can be B or C when it is small or weak, and an RCT can be S. The grade is a synthesis of study design, journal authority and clinical bindingness:

S
Highest evidence, large, methodologically first-rate studies or S3 guidelines
A
Strong evidence, solid, meaningful studies with a clear result
B
Moderate evidence, smaller or methodologically limited studies
C
Weak evidence, preliminary, indirect or contradictory findings
D
Lowest evidence, exploratory hints, single cases or expert opinion

Quality profile per study

To the left of each study there is a profile of four features, it shows the differences within a letter class.

Sample size ★
Number of participants (RCT) or included studies (review).
Blinding
Double-blind, single-blind or open-label.
Effect size
Clear benefit, mixed, no benefit or harm.
Citations / year ★
Age-adjusted citation frequency.

Key studies

1
  1. 01
    A
    Cannabis in Palliative Care: A Systematic Review of Current Evidence.
    Doppen et al. ·2022 ·Journal of pain and symptom management
    Read

Systematic Reviews and Meta-Analyses

Syntheses of RCT evidence following Cochrane and PRISMA standards.

1
A
Sample size ★★★★★
Blinding —
Effect size Mixed
Citations / year ★★★★★
● Key study
Doppen et al. ·2022 ·Journal of pain and symptom management
44 citations

Cannabis in Palliative Care: A Systematic Review of Current Evidence.

Design
Systematic Review
Sample
k = 52 Studien
n = 4.786 Pat.
Key finding

Positive treatment effects reported for some cannabis products for pain, nausea, appetite and sleep in cancer patients as well as appetite and agitation in dementia patients, however very low to low evidence quality across all included studies.

Summary

Systematic review on cannabis in palliative care; k=52 studies (20 RCTs, 32 non-randomised), n=4.786 patients (cancer n=4.491, dementia n=43, AIDS n=235, spasticity n=16). Positive treatment effects (p<0.05) for fatigue reported in cancer patients, alongside pain, nausea, appetite and sleep. Evidence quality consistently 'very low' or 'low' according to GRADE.

DOI 10.1016/j.jpainsymman.2022.06.002 ↗

Ongoing and upcoming studies

Ongoing studies are still in the trial phase and are not evidence of efficacy or safety. The information serves educational purposes only.

2
  • NCT07393672 ClinicalTrials.gov Effects of Hemp-Derived Cannabinoids on Menopause Symptoms Recruiting Phase 2 Start: 2026-02
  • NCT06747039 ClinicalTrials.gov Cannabis Extract in Fibromyalgia Syndrome - the SUNRISE Study Recruiting Start: 2024-12