Study register · detailFall-Kontroll-Studie · Cancer Risk · 2006
Association between Cannabis use and transitional cell carcinoma.
Chacko et al.·Urology
HarmGRADELow70 citations
Samplen = 156 Pat.
ControlAge-matched controls without transitional…
EndpointCannabis use
Blindingn.a.
DesignFall-Kontroll-Studie
Routeinhalativ
”Key finding
Habitual cannabis use was significantly associated with the occurrence as well as with the stage, grade, and recurrence frequency of urothelial carcinoma.
Summary
n=52 men <60 years of age with transitional cell carcinoma (TCC) vs. n=104 age-matched controls. 88,5% of TCC patients reported habitual cannabis use vs. 69,2% of controls (P=0.008). Cannabis use correlated significantly with tumor stage, grade, and recurrence frequency within the TCC group. Indication of increased TCC risk from cannabis smoking.
P
PopulationMen under 60 years of age with urothelial carcinoma (transitional cell carcinoma), n=52 cases, n=104 age-matched controls without carcinoma/hematuria history
I
InterventionHabitual cannabis use (questionnaire self-report)
C
ControlAge-matched controls without transitional cell carcinoma
O
OutcomeSignificantly higher rate of habitual cannabis use in cases vs. controls (88,5% vs. 69,2%; p=0,008); cannabis use correlated significantly with tumor stage, grade, and number of recurrences
Confidence in the evidence
Very lowLowModerateHigh
Low
The second of four GRADE levels, the effect estimate is of limited reliability.
<h4>Objectives</h4>Cannabis smoking has been implicated as a causative factor in traditionally tobacco-related tumors of the head and neck and of the lung. When associated with Cannabis use, such tumors occur in a much younger patient population than do similar tumors in tobacco smokers. Owing to the large number of young men with a history of Cannabis presenting with transitional cell carcinoma to VA facilities, this study was designed to compare the Cannabis use among young (aged less than 60 years) transitional cell carcinoma patients with that among age-matched controls.<h4>Methods</h4>Fifty-two men aged less than 60 years presenting consecutively with transitional cell carcinoma and 104 age-matched controls (defined by having no history of transitional cell carcinoma, hematuria, or irritative voiding symptoms, as well as unremarkable results on urinalysis and urine cytology) completed questionnaires about exposure to various potential carcinogens, including radiation, Agent Orange, smoked or processed meats, dyes, tobacco, and Cannabis.<h4>Results</h4>Of the 52 transitional cell carcinoma patients, 46 (88.5%) reported a history of habitual Cannabis usage, and 72 (69.2%) of the age-matched controls gave a history of habitual Cannabis use. This difference was statistically significant (P = 0.008). In those with transitional cell carcinoma, Cannabis use significantly correlated with tumor stage, grade, and number of recurrences.<h4>Conclusions</h4>Cannabis smoking might increase the risk of transitional cell carcinoma.