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Study register · detail Systematische Review · Sleep Disorders · 2014

The effects of cannabinoid administration on sleep: a systematic review of human studies

Gates et al. ·Sleep Medicine Reviews Impact 7.2
Mixed GRADE High 125 citations
Samplek = 39 Studien
EndpointSleep-related measures
Blindingunklar
DesignSystematische Review
Key finding

Cannabinoids show mixed effects on various sleep parameters without a clear efficacy profile.

Summary

Systematic review (k=39 human studies) on cannabinoid effects on sleep: findings mixed — various effects on multiple sleep parameters reported, methodological deficiencies in the majority of studies prevent clear conclusions. The review documents the heterogeneous evidence base and the need for methodologically robust studies on cannabinoids in sleep disorders.

P
PopulationAdults (various populations), pooled not reported
I
InterventionCannabinoids (various substances/routes of administration)
O
OutcomeMixed findings on various sleep aspects; no definitive conclusions due to methodological limitations
Confidence in the evidence
High

The highest of four GRADE levels, the effect estimate is very reliable.

Quality profile
Sample size ★★★★★
Blinding —
Effect size Mixed
Citations / year ★★★★★
Authors
Gates P J, Albertella L, Copeland J
DOI 10.1016/j.smrv.2014.02.005↗
Design: Systematische Review
Share
Abstract
This paper reviews the literature regarding the effects of cannabinoid administration on sleep in humans. A literature search using a set of cannabinoid and sleep-related terms was conducted across eight electronic databases. Human studies that involved the administration of cannabinoids and at least one quantitative sleep-related measure were included. Review papers, opinion pieces, letters or editorials, case studies (final N < 7), published abstracts, posters, and non-English papers were excluded. Thirty-nine publications were included in the review. Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep. Methodological issues in the majority of studies to date, however, preclude any definitive conclusion.
Indication
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