←Dependence Risk
Study register · detail Retrospektive Kohortenstudie (TriNetX-Datenbank) · Dependence Risk · 2025

Differential impact of Cannabis abuse on neurological disorders

Tabi et al. ·Journal of the Neurological Sciences
No direction reported GRADE Low 1 citations
Sample—
ControlNo cannabis abuse
DesignRetrospektive Kohortenstudie (TriNetX-Datenbank)
Summary

TriNetX cohort study across 10 neurological diseases including neuropathy; cannabis abuse associated with significantly higher emergency department visits (neuropathy: 25.8% vs. 19.3% without cannabis) and increased pain prevalence over 3-year follow-up. Propensity score matching applied.

P
PopulationPatients with neurological diseases (cluster headache, neuropathy, multiple sclerosis, stroke, TIA, Parkinson's, Alzheimer's, vascular dementia, migraine, tension headache) from the TriNetX network (143 healthcare organizations), n varies depending on disease
I
InterventionCannabis abuse (ICD-10 coded)
C
ControlNo cannabis abuse (matched via propensity score for demographic and clinical characteristics)
O
OutcomeSignificantly increased emergency department visits and pain prevalence with cannabis abuse across all diseases (e.g. neuropathy: 25,8% vs. 19,3%, RD=-0,065, p<0,001); mortality and cerebrovascular events without significant differences
Confidence in the evidence
Low

The second of four GRADE levels, the effect estimate is of limited reliability.

Quality profile
Sample size —
Blinding —
Effect size —
Citations / year ★★★★★
Authors
Tabi YA, Meyer EC
DOI 10.1016/j.jns.2025.123527↗
Design: Retrospektive Kohortenstudie (TriNetX-Datenbank)
Share
Indication
Further studies on Dependence Risk
All studies →
A Lake et al. · 2025 · The American journal of psychiatry
15 citations
High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies.
Mixed Systematic Review

Systematische Review zu High-Potency-Cannabis und Gesundheit; k=42 Studien aus 4.545 gescreenten Records. Potenz-Kategorien: 1-9% THC, 10-19%, 20-30%, Kief/Resin (~30-50%), Konzentrate (≥60%). Suggestive Assoziation zwischen höherer Potenz und 'problem cannabis use'; inkonsistente Befunde in Mental Health, Other Substance Use. Therapeutische Outcomes limitiert und gemischt. GRADE-Certainty: 'very low'. Bedarf prospektiver Studien zu kardiorespiratorischen, Krebs-, prä-/perinatalen Outcomes.

10.1176/appi.ajp.20240269 View study →
A Hasin et al. · 2015 · JAMA Psychiatry
1073 citations
Prevalence of Cannabis Use Disorders in the United States Between 2001-2002 and 2012-2013
Unclear Kohortenstudie

n=36.309 US-Erwachsene (NESARC 2001–2002 vs. 2012–2013), Prävalenz von Cannabis-Use-Disorder stieg von 1.5% auf 2.9% (p0.001); Zunahme besonders bei Älteren (≥65 Jahre: +250%) und ethnischen Minderheiten; keine Abnahme der Disorder-Rate trotz Legalisierung.

10.1001/jamapsychiatry.2015.1858 View study →
A Blanco et al. · 2016 · JAMA Psychiatry
334 citations
Cannabis Use and Risk of Psychiatric Disorders
Mixed Kohortenstudie

n=34.653, NESARC-III prospektive Kohorte über 3 Jahre; Cannabis-Konsum assoziiert mit erhöhtem Risiko für psychiatrische Störungen inkl. Depression (aOR=1.49, 95% CI 1.14-1.94, p0.01), auch nach Adjustierung für Baseline-Psychopathologie.

10.1001/jamapsychiatry.2015.3229 View study →

The impediment to action advances action. — Marcus Aurelius