Cannabis use and earlier onset of psychosis: a systematic meta-analysis.
Large et al.·Archives of General Psychiatry
HarmGRADEHigh553 citations
Samplek = 83 Studien
ControlNo substance use
EndpointDisease onset psychosis
Blindingn.a.
DesignSystematische Review + Meta-Analyse
”Key finding
Cannabis use is associated with a significantly earlier onset of psychosis by an average of 2,70 years.
Summary
Meta-analysis of k=83 studies: cannabis use associated with an average of 2,70 years earlier onset of psychotic disorders vs. non-users (SMD=-0,414); for broadly defined substance use 2,00 years earlier (SMD=-0,315). Alcohol use showed no significant association. Proportion of cannabis users significantly explained the heterogeneity of effect sizes.
P
PopulationPatients with psychotic disorder, comparison of substance users vs. non-users; pooled from 83 studies
I
InterventionCannabis use (as well as alcohol and other psychoactive substances)
C
ControlNo substance use
O
OutcomeDisease onset in cannabis users 2,70 years earlier (SMD = -0,414) than in non-users; broad substance use 2,00 years earlier (SMD = -0,315); alcohol without significant effect
Confidence in the evidence
Very lowLowModerateHigh
High
The highest of four GRADE levels, the effect estimate is very reliable.
Quality profile
Sample size★★★★★
Blinding—
Effect sizeHarm
Citations / year★★★★★
Authors
Large M, Sharma S, Compton MT, Slade T, Nielssen O.
<h4>Context</h4>A number of studies have found that the use of cannabis and other psychoactive substances is associated with an earlier onset of psychotic illness.<h4>Objective</h4>To establish the extent to which use of cannabis, alcohol, and other psychoactive substances affects the age at onset of psychosis by meta-analysis.<h4>Data sources</h4>Peer-reviewed publications in English reporting age at onset of psychotic illness in substance-using and non-substance-using groups were located using searches of CINAHL, EMBASE, MEDLINE, PsycINFO, and ISI Web of Science.<h4>Study selection</h4>Studies in English comparing the age at onset of psychosis in cohorts of patients who use substances with age at onset of psychosis in non-substance-using patients. The searches yielded 443 articles, from which 83 studies met the inclusion criteria.<h4>Data extraction</h4>Information on study design, study population, and effect size were extracted independently by 2 of us.<h4>Data synthesis</h4>Meta-analysis found that the age at onset of psychosis for cannabis users was 2.70 years younger (standardized mean difference = -0.414) than for nonusers; for those with broadly defined substance use, the age at onset of psychosis was 2.00 years younger (standardized mean difference = -0.315) than for nonusers. Alcohol use was not associated with a significantly earlier age at onset of psychosis. Differences in the proportion of cannabis users in the substance-using group made a significant contribution to the heterogeneity in the effect sizes between studies, confirming an association between cannabis use and earlier mean age at onset of psychotic illness.<h4>Conclusions</h4>The results of meta-analysis provide evidence for a relationship between cannabis use and earlier onset of psychotic illness, and they support the hypothesis that cannabis use plays a causal role in the development of psychosis in some patients. The results suggest the need for renewed warnings about the potentially harmful effects of cannabis.