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Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol.
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Summary
Two double-blind comparative studies examined delta-9-THC in children undergoing cancer chemotherapy against metoclopramide syrup and prochlorperazine tablets. THC was significantly more effective against nausea and vomiting, however not all patients achieved relief. In some children THC increased appetite. Side effects: significantly more frequent tiredness, in two cases a reported "high". Limitation: small, older studies without exact patient numbers in the abstract.
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Abstract
The antinausea and antivomiting effects of delta-9-tetrahydrocannabinol (THC) in children receiving cancer chemotherapy were compared with those of metoclopramide syrup and prochlorperazine tablets in two double-blind studies. THC was found to be a significantly better antinausea and antivomiting agent, but not all patients obtained relief of nausea and vomiting with THC. In some patients, THC enhanced appetite during a course of chemotherapy. In two patients, a "high" associated with THC administrationwas reported. Drowsiness was reported significantly more frequently with THC.
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