The prevalence of cannabis use disorder in attention-deficit hyperactivity disorder: A clinical epidemiological meta-analysis.

Froude et al. ·Journal of psychiatric research Impact 3.0

Unclear GRADE High 11 citations

Samplek = 14 Studien

ControlGeneral population or control groups…

EndpointPrevalence of CUD in ADHD

Blindingunklar

DesignMeta-Analyse

Key finding

Meta-analysis shows increased prevalence of cannabis use disorders in ADHD (lifetime 26,9%, current 19,2%) and increased risk (2,85- to 2,91-fold) compared to the general population.

Summary

Systematic review and meta-analysis on the prevalence of cannabis use disorder (CUD) in ADHD; k=14 studies. Lifetime prevalence of CUD in ADHD 26,9% (prediction interval 12,4–48,8%), current prevalence 19,2% (prediction interval 5,5–39,1%). Risk ratio: ADHD patients have a 2,85-fold increased risk for lifetime CUD and a 2,91-fold increased risk for current CUD compared to the general population.

PopulationPeople with ADHD (Attention-Deficit Hyperactivity Disorder), pooled from 14 studies

InterventionCannabis use disorder (CUD) as an exposure characteristic in ADHD

ControlGeneral population or control groups without ADHD

OutcomeLifetime prevalence of CUD in ADHD 26,9 %, current prevalence 19,2 %; risk ratio 2,85 (lifetime) and 2,91 (current) vs. general population

Confidence in the evidence

High

The highest of four GRADE levels, the effect estimate is very reliable.

Quality profile

Sample size ★★★★★

Blinding —

Effect size —

Citations / year ★★★★★

Authors

Froude AM, Fawcett EJ, Coles A, Drakes DH, Harris N, Fawcett JM

DOI 10.1016/j.jpsychires.2024.02.050↗

Design: Meta-Analyse

Abstract

Studies have shown that individuals with attention-deficit hyperactivity disorder (ADHD) pose an increased risk for developing substance use disorders. Increased cannabis product accessibility and recent legislative changes have led to increased cannabis consumption, thereby increasing the risk of cannabis use disorder (CUD). The present meta-analysis explored the lifetime and current prevalence of CUD in ADHD. A systematic review was conducted using the following databases: PubMed, PsycINFO and Web of Science. A total of 14 articles were included and used to estimate the aggregate lifetime and current prevalence of CUD in ADHD alongside risk ratios comparing increased risk of CUD in ADHD versus control samples. Mixed and random-effects models indicated that lifetime and current prevalence rates of CUD in ADHD populations were 26.9% and 19.2%, respectively (although prediction intervals ranged from 12.4% to 48.8% and 5.5%-39.1%, respectively). Analysis of the risk ratios indicated that those with ADHD were at 2.85- and 2.91-times greater risk of a lifetime or current diagnosis of CUD, respectively, than those in the general population. Our findings support the need for additional research on the prevalence of CUD in those with ADHD, as well as the inclusion of CUD screening in the treatment of ADHD.

The impediment to action advances action. — Marcus Aurelius