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Study register · detail Prospektive Längsschnittstudie (Kohorte) · Anxiety Disorders · 2008

Prospective associations between cannabis use, abuse, and dependence and panic attacks and disorder.

Zvolensky et al. ·Journal of Psychiatric Research Impact 3.0
Mixed GRADE Low 86 citations
Samplen = 1.709 Pat.
Durationfrom mean 16,6 years to mean…
EndpointPanic attacks/disorder
Blindingn.a.
DesignProspektive Längsschnittstudie (Kohorte)
Key finding

Cannabis use was prospectively associated with panic disorder, but this association was eliminated after controlling for daily cigarette smoking.

Summary

Prospective longitudinal study (n=1.709 adolescents, baseline age 16,6 years), follow-up into adulthood (mean 24,2 years); cannabis use and dependence significantly prospectively associated with increased odds for panic attacks and panic disorder. After controlling for daily cigarette smoking, no incremental effect demonstrable — no isolated proof of causality for cannabis.

P
PopulationAdolescents and young adults without panic disorder at baseline, n=1709, mean age 16,6 years (SD=1,2) at study start
I
InterventionCannabis use, abuse and dependence (naturalistically assessed, no experimental administration)
O
OutcomeCannabis use and dependence significantly prospectively associated with increased odds for panic attacks and panic disorder; association no longer incremental after controlling for daily cigarette smoking
Confidence in the evidence
Low

The second of four GRADE levels, the effect estimate is of limited reliability.

Quality profile
Sample size ★★★★★
Blinding —
Effect size Mixed
Citations / year ★★★★★
Authors
Zvolensky MJ, Lewinsohn P, Bernstein A, Schmidt NB, Buckner JD, Seeley J, Bonn-Miller MO.
DOI 10.1016/j.jpsychires.2007.10.012↗
Design: Prospektive Längsschnittstudie (Kohorte)
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Abstract
The present study prospectively evaluated cannabis use, abuse, and dependence in relation to the development of panic attacks and panic disorder. Participants at the start of the study were adolescents (n=1709) with a mean age of 16.6 years (SD=1.2; time 1) and were re-assessed 1 year later (time 2) and then again as young adults (time 3; mean age=24.2 years, SD=0.6). Results indicated that cannabis use and dependence were significantly prospectively associated with an increased odds for the development of panic attacks and panic disorder. However, cannabis was not incrementally associated with the development of panic after controlling for daily cigarette smoking. The theoretical and clinical implications of these findings are discussed.
Indication
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