←PTSD

Study register · detail Real-World-Register (App-basierte Beobachtungsstudie) · PTSD

Short and Long-Term Effects of Cannabis on Symptoms of Post-Traumatic Stress Disorder

LaFrance et al.

No direction reported GRADE Low

Samplen = 404 Pat.

DesignReal-World-Register (App-basierte Beobachtungsstudie)

Cannabinoidvollspektrum

Routeinhalativ

Summary

n=404 medical cannabis users with self-identified PTSD, 11.797 symptom trackings over 31 months via Strainprint® app. Acute inhalation reduced all PTSD symptoms (intrusive thoughts, flashbacks, irritability, anxiety) by >50% immediately after use. Higher doses predicted greater reductions in intrusions and anxiety. Long-term analysis: baseline symptomatology remained constant over time, anxiety dosing increased over time (tolerance development). Limitations: self-selection, no PTSD diagnosis validation, no placebo control.

PopulationAdults who self-identify as PTSD patients and use medical cannabis, n=404, tracked over 11.797 uses (31 months)

InterventionInhaled cannabis (various strains and dosages, documented via Strainprint® app)

OutcomeImmediate symptom reduction >50% for intrusions, flashbacks, irritability and anxiety after cannabis use (acute); baseline symptoms unchanged over time; dose escalation for anxiety (indication of tolerance)

Confidence in the evidence

Low

The second of four GRADE levels, the effect estimate is of limited reliability.

Quality profile

Sample size ★★★★★

Blinding —

Effect size —

Citations / year —

Authors

LaFrance EM, Glodosky NC, Bonn-Miller M, Cuttler C

DOI 10.1016/j.jad.2020.05.132↗

Design: Real-World-Register (App-basierte Beobachtungsstudie)

The impediment to action advances action. — Marcus Aurelius