Study register · detail
Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system
Unclear
193 citations
SampleNarrative Review
Blindingn.a.
DesignNarrative Review
Key finding
Narrative review on the role of cannabinoids and the endocannabinoid system in the regulation of nausea and vomiting; no primary study results reported.
Summary
Narrative overview on the regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Discusses central CB1/CB2 mechanisms and therapeutic potential in chemotherapy-induced and other nausea. Qualitative synthesis without systematic data extraction.
SummaryNarrative review on the role of the endocannabinoid system and exogenous cannabinoids in the regulation of nausea and vomiting; central mechanisms and therapeutic potential for treating these symptoms are discussed.
Quality profile
Sample size
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Citations / year
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Abstract
Nausea and vomiting (emesis) are important elements in defensive or protective responses that animals use to avoid ingestion or digestion of potentially harmful substances. However, these neurally-mediated responses are at times manifested as symptoms of disease and they are frequently observed as side-effects of a variety of medications, notably those used to treat cancer. Cannabis has long been known to limit or prevent nausea and vomiting from a variety of causes. This has led to extensive investigations that have revealed an important role for cannabinoids and their receptors in the regulation of nausea and emesis. With the discovery of the endocannabinoid system, novel ways to regulate both nausea and vomiting have been discovered that involve the production of endogenous cannabinoids acting centrally. Here we review recent progress in understanding the regulation of nausea and vomiting by cannabinoids and the endocannabinoid system, and we discuss the potential to utilize the endocannabinoid system in the treatment of these frequently debilitating conditions.
The impediment to action advances action.