←Addiction

Study register · detail Pilot-RCT (randomisiert, doppelblind, placebo-kontrolliert) · Addiction · 2013

Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings

Morgan et al. ·Addictive Behaviors Impact 3.2

Clear benefit GRADE Moderate 189 citations

Samplen = 24 Pat.

Duration1 week

ControlPlacebo inhaler

EndpointNumber of cigarettes smoked

Blindingdoppelblind

DesignPilot-RCT (randomisiert, doppelblind, placebo-kontrolliert)

Cannabinoidcbd

Routeinhalativ

Key finding

CBD inhalation reduced daily cigarette consumption by ~40% compared to placebo in smokers willing to quit smoking.

Summary

Pilot RCT (n=24); CBD inhaler vs. placebo in smokers with desire for nicotine withdrawal. CBD group reduced cigarette consumption by ~40% during the treatment week vs. no change in the placebo group; effect partially maintained at follow-up.

PopulationTobacco smokers with desire to quit smoking, n=24

InterventionCBD inhaler (ad hoc upon craving to smoke), 1 week

ControlPlacebo inhaler

OutcomeCBD group reduced cigarette consumption by ~40% during the treatment week; placebo group showed no significant change

Confidence in the evidence

Moderate

The third of four GRADE levels, the effect estimate is probably reliable.

Downgraded for

Imprecision

Quality profile

Sample size ★★★★★

Blinding Double-blind

Effect size Clear benefit

Citations / year ★★★★★

Authors

Morgan C J, Das R K, Joye A et al.

DOI 10.1016/j.addbeh.2013.03.011↗

Design: Pilot-RCT (randomisiert, doppelblind, placebo-kontrolliert)

Abstract

The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. We conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking. 24 smokers were randomised to receive an inhaler of CBD (n=12) or placebo (n=12) for one week, they were instructed to use the inhaler when they felt the urge to smoke. Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by ~40% during treatment. Results also indicated some maintenance of this effect at follow-up. These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.

The impediment to action advances action. — Marcus Aurelius