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Cannabidiol as a Potential Treatment for Anxiety Disorders
Unclear
678 citations
SampleNarrative Review
Blindingn.a.
DesignNarrative Review
Cannabinoidcbd
Key finding
Preclinical evidence strongly supports CBD for several anxiety disorders with acute administration; clinical evidence is limited and restricted to acute dosing.
Summary
Narrative review on CBD in anxiety disorders; preclinical evidence strongly supports efficacy in generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder and PTSD with acute administration. Human data confirm anxiolytic effect, though limited to acute dosing. Chronic dosing and clinical populations have so far been insufficiently studied. Conclusion: considerable potential, further controlled studies required.
SummaryNarrative review on the efficacy of CBD as a treatment option for anxiety disorders (generalized anxiety disorder, panic disorder, social anxiety disorder, OCD, PTSD): Preclinical and human evidence supports anxiolytic effects with acute administration, but studies on chronic dosing and in clinical populations are lacking.
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Abstract
Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD's potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.
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