←Autism Spectrum Disorder

Study register · detail Retrospektive Kohortenstudie · Autism Spectrum Disorder · 2019

Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study

Aran et al. ·Journal of Autism and Developmental Disorders Impact 2.2

Mixed GRADE Very low 224 citations

Samplen = 60 Pat.

EndpointCGIC

Blindingn.a.

DesignRetrospektive Kohortenstudie

Cannabinoidcbd

Routeoral

Key finding

CBD-rich cannabis improved behavioral outbursts in the majority of children, but was associated with relevant side effects including a psychotic event.

Summary

Retrospective feasibility study of CBD-rich cannabis in n=60 children with autism spectrum disorder and severe behavioral problems (age 11,8±3,5 years, 77% low-functioning). 61% showed marked or very marked improvement in behavioral outbursts (Caregiver Global Impression of Change). Most common adverse events: sleep disturbances (14%), irritability (9%), loss of appetite (9%). One psychotic event with higher THC content.

PopulationChildren with autism spectrum disorder (ASD) and severe behavioral problems, n=60, age 5,0–17,5 years (mean 11,8 ± 3,5 yrs.), 77% low-functioning, 83% male

InterventionCBD-rich cannabis (cannabidiol-rich preparation, oral), dosage not specified

OutcomeBehavioral outbursts rated as 'much improved' or 'very much improved' in 61% of patients (CGIC); adverse events: sleep disturbances 14%, irritability 9%, loss of appetite 9%; one transient serious psychotic event in a girl with higher THC content

Confidence in the evidence

Very low

The lowest GRADE level, the effect estimate remains uncertain.

Downgraded for

Imprecision

Quality profile

Sample size ★★★★★

Blinding —

Effect size Mixed

Citations / year ★★★★★

Authors

Aran A, Cassuto H, Lubotzky A et al.

DOI 10.1007/s10803-018-3808-2↗

Design: Retrospektive Kohortenstudie

The impediment to action advances action. — Marcus Aurelius