Study register · detail
Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.
No direction reported
Samplen = 32
Summary
Double-blind, randomized cross-over study (n=32) compared oral nabilone with intravenous metoclopramide for the treatment of cisplatin-induced nausea and vomiting. No difference in overall incidence or severity of vomiting between the two treatments; a subgroup benefited more from metoclopramide. Side effects corresponded to the pharmacological profile of the substances. Limitation: small sample size, no superiority of nabilone.
Quality profile
Sample size
★★★★★
Blinding
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Effect size
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Citations / year
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Abstract
Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg-1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.
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