←Parkinson Disease
Study register · detail Patientenumfrage (anonymer Fragebogen) · Parkinson Disease · 2004

Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms.

Venderová et al. ·Movement Disorders Impact 3.9
No direction reported GRADE Low 175 citations
Samplen = 339 Pat.
DesignPatientenumfrage (anonymer Fragebogen)
Summary

Anonymous questionnaire survey of n=339 Parkinson's patients: 25% reported cannabis use; of these, 45,9% described a subjective improvement of motor symptoms. No control arm; purely reported patient perspective.

P
PopulationParkinson's patients from the Prague Movement Disorder Centre, n=339 questionnaire respondents, of whom 25% with cannabis experience
I
InterventionCannabis (form of administration and dose not specified, retrospective self-report)
O
Outcome45,9% of cannabis users report subjective improvement of motor symptoms
Confidence in the evidence
Low

The second of four GRADE levels, the effect estimate is of limited reliability.

Quality profile
Sample size ★★★★★
Blinding —
Effect size —
Citations / year ★★★★★
Authors
Venderová K, Růzicka E, Vorísek V, Visnovský P.
DOI 10.1002/mds.20111↗
Design: Patientenumfrage (anonymer Fragebogen)
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Abstract
An anonymous questionnaire sent to all patients attending the Prague Movement Disorder Centre revealed that 25% of 339 respondents had taken cannabis and 45.9% of these described some form of benefit.
Indication
Further studies on Parkinson Disease
All studies →
A Figura et al. · 2022 · Neurologia i neurochirurgia polska
19 citations
Cannabis in Parkinson's Disease - the patient's perspective versus clinical trials: a systematic literature review.
No benefit demonstrated Systematic Review

Systematische Review zu Cannabis bei Parkinson; k=7 randomisierte Studien identifiziert. Ergebnisse unterstützen KEINE Wirksamkeit von Cannabinoiden bei motorischen Symptomen der Parkinson-Krankheit. Schlussfolgerung: derzeit unzureichende Datenlage für Cannabinoid-Einsatz bei PD-Patienten.

10.5603/pjnns.a2022.0004 View study →
A Liu et al. · 2024 · Movement disorders
19 citations
Short-Term Cannabidiol with Delta-9-Tetrahydrocannabinol in Parkinson's Disease: A Randomized Trial.
No benefit demonstrated RCT

RCT n=61 (CBD/THC n=31, Placebo n=30), 2 Wochen Titration auf finale Dosis 191,8±48,9 mg CBD + 6,4±1,6 mg THC täglich. Primärer Endpunkt motor MDS-UPDRS: Reduktion -4,57 (95% CI -8,11 bis -1,03; p=0,013) in CBD/THC-Gruppe vs. -2,77 (-4,92 bis -0,61; p=0,014) in Placebo; Gruppen-Differenz nicht signifikant: -1,80 (-5,88 bis 2,27; p=0,379). Kein Benefit, möglicherweise verschlechterte Kognition und Schlaf; starker Placebo-Effekt. Nebenwirkungen mild, häufiger in CBD/THC-Gruppe.

10.1002/mds.29768 View study →
A Peball et al. · 2020 · Annals of neurology
118 citations
Non-Motor Symptoms in Parkinson's Disease are Reduced by Nabilone.
Mixed RCT

Phase-II-RCT, n=47 Parkinson-Patienten mit stabiler Motorik aber störenden Non-Motor-Symptoms (NMS, MDS-UPDRS-I ≥4). Open-label Nabilone-Titration (0,25–1 mg 2×/d), dann Randomisierung Responder zu Nabilone vs. Placebo (n=19). Primärer Endpunkt MDS-UPDRS-I nach 4 Wochen: Placebo-Gruppe verschlechterte sich um 2,63 Punkte (95% CI 1,53–3,74, p=0,002), Nabilone-Gruppe nur um 1,00 Punkte (95% CI −0,16–2,16, p=0,280); Differenz 1,63 Punkte (95% CI 0,09–3,18, p=0,030, Effektgröße 0,66). Positive Effekte v.a. auf Angst und nächtliche Schlafprobleme. 77% AEs in Titrationsphase (meist transient), keine schwerwiegenden AEs.

10.1002/ana.25864 View study →

The impediment to action advances action. — Marcus Aurelius